Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy

The antischistosomal prodrug oxamniquine is activated by a sulfotransferase (SULT) in the parasitic flatworm Schistosoma mansoni. Of the three main human schistosome species, only S. mansoni is sensitive to oxamniquine therapy despite the presence of SULT orthologs in Schistosoma hematobium and Schi...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Taylor, Alexander B., Roberts, Kenneth M., Cao, Xiaohang, Clark, Nathaniel E., Holloway, Stephen P., Donati, Enrica, Polcaro, Chiara M., Pica-Mattoccia, Livia, Tarpley, Reid S., McHardy, Stanton F., Cioli, Donato, LoVerde, Philip T., Fitzpatrick, Paul F., Hart, P. John
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Protein Structure and Folding
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500785/
https://ncbi.nlm.nih.gov/pubmed/28536265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.766527
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