Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy

The antischistosomal prodrug oxamniquine is activated by a sulfotransferase (SULT) in the parasitic flatworm Schistosoma mansoni. Of the three main human schistosome species, only S. mansoni is sensitive to oxamniquine therapy despite the presence of SULT orthologs in Schistosoma hematobium and Schi...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Taylor, Alexander B., Roberts, Kenneth M., Cao, Xiaohang, Clark, Nathaniel E., Holloway, Stephen P., Donati, Enrica, Polcaro, Chiara M., Pica-Mattoccia, Livia, Tarpley, Reid S., McHardy, Stanton F., Cioli, Donato, LoVerde, Philip T., Fitzpatrick, Paul F., Hart, P. John
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500785/
https://ncbi.nlm.nih.gov/pubmed/28536265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.766527
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