Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy

The antischistosomal prodrug oxamniquine is activated by a sulfotransferase (SULT) in the parasitic flatworm Schistosoma mansoni. Of the three main human schistosome species, only S. mansoni is sensitive to oxamniquine therapy despite the presence of SULT orthologs in Schistosoma hematobium and Schi...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Taylor, Alexander B., Roberts, Kenneth M., Cao, Xiaohang, Clark, Nathaniel E., Holloway, Stephen P., Donati, Enrica, Polcaro, Chiara M., Pica-Mattoccia, Livia, Tarpley, Reid S., McHardy, Stanton F., Cioli, Donato, LoVerde, Philip T., Fitzpatrick, Paul F., Hart, P. John
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500785/
https://ncbi.nlm.nih.gov/pubmed/28536265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.766527
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