An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans

Currently there is only one method of treatment for human schistosomiasis, the drug praziquantel. Strong selective pressure has caused a serious concern for a rise in resistance to praziquantel leading to the necessity for additional pharmaceuticals, with a distinctly different mechanism of action,...

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Publicado en:PLoS Negl Trop Dis
Autores principales: Guzman, Meghan A., Rugel, Anastasia R., Tarpley, Reid S., Alwan, Sevan N., Chevalier, Frédéric D., Kovalskyy, Dmytro P., Cao, Xiaohang, Holloway, Stephen P., Anderson, Timothy J. C., Taylor, Alexander B., McHardy, Stanton F., LoVerde, Philip T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7454593/
https://ncbi.nlm.nih.gov/pubmed/32810153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0008517
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