An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans

Currently there is only one method of treatment for human schistosomiasis, the drug praziquantel. Strong selective pressure has caused a serious concern for a rise in resistance to praziquantel leading to the necessity for additional pharmaceuticals, with a distinctly different mechanism of action,...

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Библиографические подробности
Опубликовано в: :PLoS Negl Trop Dis
Главные авторы: Guzman, Meghan A., Rugel, Anastasia R., Tarpley, Reid S., Alwan, Sevan N., Chevalier, Frédéric D., Kovalskyy, Dmytro P., Cao, Xiaohang, Holloway, Stephen P., Anderson, Timothy J. C., Taylor, Alexander B., McHardy, Stanton F., LoVerde, Philip T.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2020
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7454593/
https://ncbi.nlm.nih.gov/pubmed/32810153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0008517
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