An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans

Currently there is only one method of treatment for human schistosomiasis, the drug praziquantel. Strong selective pressure has caused a serious concern for a rise in resistance to praziquantel leading to the necessity for additional pharmaceuticals, with a distinctly different mechanism of action,...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Guzman, Meghan A., Rugel, Anastasia R., Tarpley, Reid S., Alwan, Sevan N., Chevalier, Frédéric D., Kovalskyy, Dmytro P., Cao, Xiaohang, Holloway, Stephen P., Anderson, Timothy J. C., Taylor, Alexander B., McHardy, Stanton F., LoVerde, Philip T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7454593/
https://ncbi.nlm.nih.gov/pubmed/32810153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0008517
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