Lowering Endogenous Cathepsin D Abundance Results in Reactive Oxygen Species Accumulation and Cell Senescence

Cathepsin D is reportedly to be closely associated with tumor development, migration, and invasion, but its pathological mechanism is not fully elucidated. We aimed to evaluate phenotypic changes and molecular events in response to cathepsin D knockdown. Lowering endogenous cathepsin D abundance (CR...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Su, Siyuan, Zhu, Xu, Lin, Liang, Chen, Xianwei, Wang, Yang, Zi, Jin, Dong, Yusheng, Xie, Yingying, Zhu, Yinghui, Zhang, Ju, Zhu, Jianhui, Xu, Dan, Xu, Ningzhi, Lou, Xiaomin, Liu, Siqi
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500756/
https://ncbi.nlm.nih.gov/pubmed/26657266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.050179
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