Lowering Endogenous Cathepsin D Abundance Results in Reactive Oxygen Species Accumulation and Cell Senescence

Cathepsin D is reportedly to be closely associated with tumor development, migration, and invasion, but its pathological mechanism is not fully elucidated. We aimed to evaluate phenotypic changes and molecular events in response to cathepsin D knockdown. Lowering endogenous cathepsin D abundance (CR...

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Библиографические подробности
Опубликовано в: :Mol Cell Proteomics
Главные авторы: Su, Siyuan, Zhu, Xu, Lin, Liang, Chen, Xianwei, Wang, Yang, Zi, Jin, Dong, Yusheng, Xie, Yingying, Zhu, Yinghui, Zhang, Ju, Zhu, Jianhui, Xu, Dan, Xu, Ningzhi, Lou, Xiaomin, Liu, Siqi
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Biochemistry and Molecular Biology 2017
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500756/
https://ncbi.nlm.nih.gov/pubmed/26657266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.050179
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