Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells

MODY1 is a maturity-onset monogenic diabetes, caused by heterozygous mutations of the HNF4A gene. To date the cellular and molecular mechanisms leading to disease onset remain largely unknown. In this study, we demonstrate that insulin-positive cells can be generated in vitro from human induced plur...

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Publicado en:Sci Rep
Main Authors: Vethe, Heidrun, Bjørlykke, Yngvild, Ghila, Luiza M., Paulo, Joao A., Scholz, Hanne, Gygi, Steven P., Chera, Simona, Ræder, Helge
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500592/
https://ncbi.nlm.nih.gov/pubmed/28684784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04979-w
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