Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells

MODY1 is a maturity-onset monogenic diabetes, caused by heterozygous mutations of the HNF4A gene. To date the cellular and molecular mechanisms leading to disease onset remain largely unknown. In this study, we demonstrate that insulin-positive cells can be generated in vitro from human induced plur...

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Publicat a:Sci Rep
Autors principals: Vethe, Heidrun, Bjørlykke, Yngvild, Ghila, Luiza M., Paulo, Joao A., Scholz, Hanne, Gygi, Steven P., Chera, Simona, Ræder, Helge
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500592/
https://ncbi.nlm.nih.gov/pubmed/28684784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04979-w
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