Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells

MODY1 is a maturity-onset monogenic diabetes, caused by heterozygous mutations of the HNF4A gene. To date the cellular and molecular mechanisms leading to disease onset remain largely unknown. In this study, we demonstrate that insulin-positive cells can be generated in vitro from human induced plur...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Vethe, Heidrun, Bjørlykke, Yngvild, Ghila, Luiza M., Paulo, Joao A., Scholz, Hanne, Gygi, Steven P., Chera, Simona, Ræder, Helge
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500592/
https://ncbi.nlm.nih.gov/pubmed/28684784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04979-w
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