The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation

Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to assess whether Wnt-modulation could promote the final protocol stages of β-cell m...

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Bibliografske podrobnosti
izdano v:Front Endocrinol (Lausanne)
Main Authors: Vethe, Heidrun, Ghila, Luiza, Berle, Magnus, Hoareau, Laurence, Haaland, Øystein A., Scholz, Hanne, Paulo, Joao A., Chera, Simona, Ræder, Helge
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Endocrinology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518024/
https://ncbi.nlm.nih.gov/pubmed/31139151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2019.00293
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