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In Vitro Transport Activity and Trafficking of MRP2/ABCC2 Polymorphic Variants

PURPOSE: Multidrug resistance-associated protein 2 (MRP2/ABCC2) is an efflux pump that removes drugs and chemicals from cells. We sought to characterize the expression, trafficking and in vitro activity of seven single nucleotide polymorphisms (SNPs) in the ABCC2 gene. METHODS: ABCC2 SNPs were gener...

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Bibliographische Detailangaben
Veröffentlicht in:Pharm Res
Hauptverfasser: Wen, Xia, Joy, Melanie S., Aleksunes, Lauren M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500460/
https://ncbi.nlm.nih.gov/pubmed/28405913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-017-2160-0
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