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In Vitro Transport Activity and Trafficking of MRP2/ABCC2 Polymorphic Variants

PURPOSE: Multidrug resistance-associated protein 2 (MRP2/ABCC2) is an efflux pump that removes drugs and chemicals from cells. We sought to characterize the expression, trafficking and in vitro activity of seven single nucleotide polymorphisms (SNPs) in the ABCC2 gene. METHODS: ABCC2 SNPs were gener...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Wen, Xia, Joy, Melanie S., Aleksunes, Lauren M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500460/
https://ncbi.nlm.nih.gov/pubmed/28405913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-017-2160-0
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