An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII

Coagulation Factor VIII is activated by an ordered limited thrombin proteolysis with different catalytic efficiency at three P1 Arginine residues: Arg(759)> Arg(1708)>Arg(391), indicating the flanking residues of the latter to be less optimal. This study aimed to investigate, in silico and in...

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Bibliographic Details
Published in:PLoS One
Main Authors: Pezeshkpoor, Behnaz, Schreck, Ursula, Biswas, Arijit, Driesen, Julia, Berkemeier, Ann-Cristin, Pavlova, Anna, Müller, Jens, Oldenburg, Johannes
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500338/
https://ncbi.nlm.nih.gov/pubmed/28683085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180456
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