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An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII
Coagulation Factor VIII is activated by an ordered limited thrombin proteolysis with different catalytic efficiency at three P1 Arginine residues: Arg(759)> Arg(1708)>Arg(391), indicating the flanking residues of the latter to be less optimal. This study aimed to investigate, in silico and in...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5500338/ https://ncbi.nlm.nih.gov/pubmed/28683085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180456 |
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