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PRL-3 promotes telomere deprotection and chromosomal instability
Phosphatase of regenerating liver (PRL-3) promotes cell invasiveness, but its role in genomic integrity remains unknown. We report here that shelterin component RAP1 mediates association between PRL-3 and TRF2. In addition, TRF2 and RAP1 assist recruitment of PRL-3 to telomeric DNA. Silencing of PRL...
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| 出版年: | Nucleic Acids Res |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5499835/ https://ncbi.nlm.nih.gov/pubmed/28482095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx392 |
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