PRL-3 promotes telomere deprotection and chromosomal instability

Phosphatase of regenerating liver (PRL-3) promotes cell invasiveness, but its role in genomic integrity remains unknown. We report here that shelterin component RAP1 mediates association between PRL-3 and TRF2. In addition, TRF2 and RAP1 assist recruitment of PRL-3 to telomeric DNA. Silencing of PRL...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Lian, Shenyi, Meng, Lin, Yang, Yongyong, Ma, Ting, Xing, Xiaofang, Feng, Qin, Song, Qian, Liu, Caiyun, Tian, Zhihua, Qu, Like, Shou, Chengchao
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499835/
https://ncbi.nlm.nih.gov/pubmed/28482095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx392
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