Knockdown of PRL-3 increases mitochondrial superoxide anion production through transcriptional regulation of RAP1

BACKGROUND: Phosphatase of regenerating liver-3 (PRL-3) has been shown to be highly expressed in various types of cancers and is related to poor prognosis. Our previous study showed that silencing of PRL-3 leads to increased reactive oxygen species (ROS). However, the mechanism of PRL-3 regulating R...

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Vydáno v:Cancer Manag Res
Hlavní autoři: Yang, Yongyong, Lian, Shenyi, Meng, Lin, Tian, Zhihua, Feng, Qin, Wang, Yue, Wang, Ping, Qu, Like, Shou, Chengchao
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2018
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215920/
https://ncbi.nlm.nih.gov/pubmed/30464607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S165344
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