PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling

BACKGROUND: Phosphatase of regenerating liver-3 (PRL-3) plays a causative role in tumor metastasis, but the underlying mechanisms are not well understood. In our previous study, we observed that PRL-3 could decrease tyrosine phosphorylation of integrin β1 and enhance activation of ERK1/2 in HEK293 c...

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Bibliografiske detaljer
Main Authors:	Peng, Lirong, Xing, Xiaofang, Li, Weijun, Qu, Like, Meng, Lin, Lian, Shenyi, Jiang, Beihai, Wu, Jian, Shou, Chengchao
Format:	Artigo
Sprog:	Inglês
Udgivet:	BioMed Central 2009
Fag:	Research
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2792223/ https://ncbi.nlm.nih.gov/pubmed/19930715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-110
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PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling

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