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Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases

S-Adenosyl methionine (SAM)-dependent C-methyltransferases are responsible for the C2-methylation of 3-ketoacyl-acyl carrier protein (ACP) intermediates to give the corresponding 2-methy-3-ketoacyl-ACP products during bacterial polyketide biosynthesis mediated by trans-AT polyketide synthases that l...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Xie, Xinqiang, Khosla, Chaitan, Cane, David E.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499234/
https://ncbi.nlm.nih.gov/pubmed/28430424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b02911
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