A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks

Of the many types of DNA damage, DNA double-strand breaks (DSBs) are probably the most deleterious. Mounting evidence points to an intricate relationship between DSBs and transcription. A cell system in which the impact on transcription can be investigated at precisely mapped genomic DSBs is essenti...

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Publicat a:Nat Commun
Autors principals: Iannelli, Fabio, Galbiati, Alessandro, Capozzo, Ilaria, Nguyen, Quan, Magnuson, Brian, Michelini, Flavia, D’Alessandro, Giuseppina, Cabrini, Matteo, Roncador, Marco, Francia, Sofia, Crosetto, Nicola, Ljungman, Mats, Carninci, Piero, d’Adda di Fagagna, Fabrizio
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499205/
https://ncbi.nlm.nih.gov/pubmed/28561034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15656
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