Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks

The DNA damage response (DDR) preserves genomic integrity. Small non-coding RNAs termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for DDR activation. Here we show that active DDRNAs specifically localize to their damaged homologous genomic sites in a transcription-depe...

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Pubblicato in:Nat Cell Biol
Autori principali: Michelini, Flavia, Pitchiaya, Sethuramasundaram, Vitelli, Valerio, Sharma, Sheetal, Gioia, Ubaldo, Pessina, Fabio, Cabrini, Matteo, Wang, Yejun, Capozzo, Ilaria, Iannelli, Fabio, Matti, Valentina, Francia, Sofia, Shivashankar, G.V., Walter, Nils G., d’Adda di Fagagna, Fabrizio
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714282/
https://ncbi.nlm.nih.gov/pubmed/29180822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3643
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