DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining

The DNA damage response (DDR) is the signaling cascade that recognizes DNA double-strand breaks (DSBs) and promotes their resolution via the DNA repair pathways of non-homologous end joining (NHEJ) or homologous recombination (HR). We and others have shown that DDR activation requires DROSHA; howeve...

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Udgivet i:J Cell Sci
Main Authors: Cabrini, Matteo, Roncador, Marco, Galbiati, Alessandro, Cipolla, Lina, Maffia, Antonio, Iannelli, Fabio, Sabbioneda, Simone, d’Adda di Fagagna, Fabrizio, Francia, Sofia
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8015226/
https://ncbi.nlm.nih.gov/pubmed/33558311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.249706
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