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Localization of the Placental BCRP/ABCG2 Transporter to Lipid Rafts: Role for Cholesterol in Mediating Efflux Activity

INTRODUCTION: The breast cancer resistance protein (BCRP/ABCG2) is an efflux transporter in the placental barrier. By transporting chemicals from the fetal to the maternal circulation, BCRP limits fetal exposure to a range of drugs, toxicants, and endobiotics such as bile acids and hormones. The pur...

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Dettagli Bibliografici
Pubblicato in:Placenta
Autori principali: Szilagyi, John T., Vetrano, Anna M., Laskin, Jeffrey D., Aleksunes, Lauren M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497756/
https://ncbi.nlm.nih.gov/pubmed/28623970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.placenta.2017.04.006
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