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The DBA/2J haplotype on distal chromosome 2 reduces Mertk expression, restricts efferocytosis and increases susceptibility to atherosclerosis

OBJECTIVE: Arch atherosclerosis 4 (Aath4) is a quantitative trait locus for atherosclerotic plaque formation in the inner curve of the aortic arch previously identified in an F2 cross of Apoe(−/−) mice on DBA/2J and 129S6 backgrounds. Mertk, coding for a ligand-activated transmembrane tyrosine kinas...

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Bibliografiske detaljer
Udgivet i:Arterioscler Thromb Vasc Biol
Main Authors: Kayashima, Yukako, Makhanova, Natalia, Maeda, Nobuyo
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497749/
https://ncbi.nlm.nih.gov/pubmed/28473436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309522
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