Genetic architecture of atherosclerosis dissected by QTL analyses in three F2 intercrosses of apolipoprotein E-null mice on C57BL6/J, DBA/2J and 129S6/SvEvTac backgrounds

Quantitative trait locus (QTL) analyses of intercross populations between widely used mouse inbred strains provide a powerful approach for uncovering genetic factors that influence susceptibility to atherosclerosis. Epistatic interactions are common in complex phenotypes and depend on genetic backgr...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Makhanova, Natalia, Morgan, Andrew P., Kayashima, Yukako, Makhanov, Andrei, Hiller, Sylvia, Zhilicheva, Svetlana, Xu, Longquan, Pardo-Manuel de Villena, Fernando, Maeda, Nobuyo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570285/
https://ncbi.nlm.nih.gov/pubmed/28837567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182882
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