Moderate Autophagy Inhibits Vascular Smooth Muscle Cell Senescence to Stabilize Progressed Atherosclerotic Plaque via the mTORC1/ULK1/ATG13 Signal Pathway

In order to investigate the effects of autophagy induced by rapamycin in the development of atherosclerosis plaque we established murine atherosclerosis model which was induced in ApoE(−/−) mice by high fat and cholesterol diet (HFD) for 16 weeks. Rapamycin and 3-Methyladenine (MA) were used as auto...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Luo, Zhenli, Xu, Wenhuan, Ma, Sai, Qiao, Hongyu, Gao, Lei, Zhang, Ran, Yang, Bo, Qiu, Ya, Chen, Jiangwei, Zhang, Ming, Tao, Bo, Cao, Feng, Wang, Yabin
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497616/
https://ncbi.nlm.nih.gov/pubmed/28713484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/3018190
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