Polyglycerol-opioid conjugate produces analgesia devoid of side effects

Novel painkillers are urgently needed. The activation of opioid receptors in peripheral inflamed tissue can reduce pain without central adverse effects such as sedation, apnoea, or addiction. Here, we use an unprecedented strategy and report the synthesis and analgesic efficacy of the standard opioi...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:eLife
Main Authors: González-Rodríguez, Sara, Quadir, Mohiuddin A, Gupta, Shilpi, Walker, Karolina A, Zhang, Xuejiao, Spahn, Viola, Labuz, Dominika, Rodriguez-Gaztelumendi, Antonio, Schmelz, Martin, Joseph, Jan, Parr, Maria K, Machelska, Halina, Haag, Rainer, Stein, Christoph
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496737/
https://ncbi.nlm.nih.gov/pubmed/28673386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27081
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