Polyglycerol-opioid conjugate produces analgesia devoid of side effects

Novel painkillers are urgently needed. The activation of opioid receptors in peripheral inflamed tissue can reduce pain without central adverse effects such as sedation, apnoea, or addiction. Here, we use an unprecedented strategy and report the synthesis and analgesic efficacy of the standard opioi...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: González-Rodríguez, Sara, Quadir, Mohiuddin A, Gupta, Shilpi, Walker, Karolina A, Zhang, Xuejiao, Spahn, Viola, Labuz, Dominika, Rodriguez-Gaztelumendi, Antonio, Schmelz, Martin, Joseph, Jan, Parr, Maria K, Machelska, Halina, Haag, Rainer, Stein, Christoph
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2017
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496737/
https://ncbi.nlm.nih.gov/pubmed/28673386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27081
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