Polyglycerol-opioid conjugate produces analgesia devoid of side effects

Novel painkillers are urgently needed. The activation of opioid receptors in peripheral inflamed tissue can reduce pain without central adverse effects such as sedation, apnoea, or addiction. Here, we use an unprecedented strategy and report the synthesis and analgesic efficacy of the standard opioi...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: González-Rodríguez, Sara, Quadir, Mohiuddin A, Gupta, Shilpi, Walker, Karolina A, Zhang, Xuejiao, Spahn, Viola, Labuz, Dominika, Rodriguez-Gaztelumendi, Antonio, Schmelz, Martin, Joseph, Jan, Parr, Maria K, Machelska, Halina, Haag, Rainer, Stein, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496737/
https://ncbi.nlm.nih.gov/pubmed/28673386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27081
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