Opioid receptor signaling, analgesic and side effects induced by a computationally designed pH-dependent agonist

Novel pain killers without adverse effects are urgently needed. Opioids induce central and intestinal side effects such as respiratory depression, sedation, addiction, and constipation. We have recently shown that a newly designed agonist with a reduced acid dissociation constant (pK(a)) abolished p...

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Udgivet i:Sci Rep
Main Authors: Spahn, Viola, Del Vecchio, Giovanna, Rodriguez-Gaztelumendi, Antonio, Temp, Julia, Labuz, Dominika, Kloner, Michael, Reidelbach, Marco, Machelska, Halina, Weber, Marcus, Stein, Christoph
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997768/
https://ncbi.nlm.nih.gov/pubmed/29895890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27313-4
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