pK(a) of opioid ligands as a discriminating factor for side effects

The non-selective activation of central and peripheral opioid receptors is a major shortcoming of currently available opioids. Targeting peripheral opioid receptors is a promising strategy to preclude side effects. Recently, we showed that fentanyl-derived μ-opioid receptor (MOR) agonists with reduc...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Del Vecchio, Giovanna, Labuz, Dominika, Temp, Julia, Seitz, Viola, Kloner, Michael, Negrete, Roger, Rodriguez-Gaztelumendi, Antonio, Weber, Marcus, Machelska, Halina, Stein, Christoph
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920366/
https://ncbi.nlm.nih.gov/pubmed/31852967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55886-1
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