TGF-β(1) stimulates HDAC4 nucleus-to-cytoplasm translocation and NADPH oxidase 4-derived reactive oxygen species in normal human lung fibroblasts

Myofibroblasts are important mediators of fibrogenesis; thus blocking fibroblast-to-myofibroblast differentiation (FMD) may be an effective strategy to treat pulmonary fibrosis (PF). Previously, we reported that histone deacetylase 4 (HDAC4) activity is necessary for transforming growth factor-β(1)...

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Vydáno v:Am J Physiol Lung Cell Mol Physiol
Hlavní autoři: Guo, Weichao, Saito, Shigeki, Sanchez, Cecilia G., Zhuang, Yan, Gongora Rosero, Rafael E., Shan, Bin, Luo, Fayong, Lasky, Joseph A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495947/
https://ncbi.nlm.nih.gov/pubmed/28336812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00256.2016
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