Tubastatin ameliorates pulmonary fibrosis by targeting the TGFβ-PI3K-Akt pathway

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal disease. Histone deacetylase 6 (HDAC6) alters function and fate of various proteins via deacetylation of lysine residues, and is implicated in TGF-β1-induced EMT (epithelial-mesenchymal transition). However, the role...

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Udgivet i:PLoS One
Main Authors: Saito, Shigeki, Zhuang, Yan, Shan, Bin, Danchuk, Svitlana, Luo, Fayong, Korfei, Martina, Guenther, Andreas, Lasky, Joseph A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5646855/
https://ncbi.nlm.nih.gov/pubmed/29045477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186615
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