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Tubastatin ameliorates pulmonary fibrosis by targeting the TGFβ-PI3K-Akt pathway
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal disease. Histone deacetylase 6 (HDAC6) alters function and fate of various proteins via deacetylation of lysine residues, and is implicated in TGF-β1-induced EMT (epithelial-mesenchymal transition). However, the role...
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| Publicado en: | PLoS One |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5646855/ https://ncbi.nlm.nih.gov/pubmed/29045477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186615 |
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