HDAC8 inhibition ameliorates pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative lung disease, and fibroblast-myofibroblast differentiation (FMD) is thought to be a key event in the pathogenesis of IPF. Histone deacetylase-8 (HDAC8) has been shown to associate with α-smooth muscle actin (α-SMA; a marker of FMD) and regu...

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Bibliographic Details
Published in:Am J Physiol Lung Cell Mol Physiol
Main Authors: Saito, Shigeki, Zhuang, Yan, Suzuki, Takayoshi, Ota, Yosuke, Bateman, Marjorie E., Alkhatib, Ala L., Morris, Gilbert F., Lasky, Joseph A.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383499/
https://ncbi.nlm.nih.gov/pubmed/30358439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00551.2017
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