Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors

Botulinum neurotoxin B is a Food and Drug Administration-approved therapeutic toxin. However, it has lower binding affinity toward the human version of its major receptor, synaptotagmin II (h-Syt II), compared to mouse Syt II, because of a residue difference. Increasing the binding affinity to h-Syt...

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Udgivet i:Nat Commun
Main Authors: Tao, Liang, Peng, Lisheng, Berntsson, Ronnie P.-A., Liu, Sai Man, Park, SunHyun, Yu, Feifan, Boone, Christopher, Palan, Shilpa, Beard, Matthew, Chabrier, Pierre-Etienne, Stenmark, Pål, Krupp, Johannes, Dong, Min
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495808/
https://ncbi.nlm.nih.gov/pubmed/28674381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00064-y
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