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Structure of dual receptor binding to botulinum neurotoxin B

Botulinum neurotoxins are highly toxic, and bind two receptors to achieve their high affinity and specificity for neurons. Here we present the first structure of a botulinum neurotoxin bound to both its receptors. We determine the 2.3 Å structure of a ternary complex of botulinum neurotoxin type B b...

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Detalhes bibliográficos
Main Authors: Berntsson, Ronnie P-A, Peng, Lisheng, Dong, Min, Stenmark, Pål
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752466/
https://ncbi.nlm.nih.gov/pubmed/23807078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3058
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