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Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors
Botulinum neurotoxin B is a Food and Drug Administration-approved therapeutic toxin. However, it has lower binding affinity toward the human version of its major receptor, synaptotagmin II (h-Syt II), compared to mouse Syt II, because of a residue difference. Increasing the binding affinity to h-Syt...
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| Publicat a: | Nat Commun |
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| Autors principals: | , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5495808/ https://ncbi.nlm.nih.gov/pubmed/28674381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00064-y |
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