HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium

Hemodynamic forces regulate vascular functions. Disturbed flow (DF) occurs in arterial bifurcations and curvatures, activates endothelial cells (ECs), and results in vascular inflammation and ultimately atherosclerosis. However, how DF alters EC metabolism, and whether resulting metabolic changes in...

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Udgivet i:eLife
Main Authors: Wu, David, Huang, Ru-Ting, Hamanaka, Robert B, Krause, Matt, Oh, Myung-Jin, Kuo, Cheng-Hsiang, Nigdelioglu, Recep, Meliton, Angelo Y, Witt, Leah, Dai, Guohao, Civelek, Mete, Prabhakar, Nanduri R, Fang, Yun, Mutlu, Gökhan M
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495571/
https://ncbi.nlm.nih.gov/pubmed/28556776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25217
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