Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production

TGF-β promotes excessive collagen deposition in fibrotic diseases such as idiopathic pulmonary fibrosis (IPF). The amino acid composition of collagen is unique due to its high (33%) glycine content. Here, we report that TGF-β induces expression of glycolytic genes and increases glycolytic flux. TGF-...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Nigdelioglu, Recep, Hamanaka, Robert B., Meliton, Angelo Y., O'Leary, Erin, Witt, Leah J., Cho, Takugo, Sun, Kaitlyn, Bonham, Catherine, Wu, David, Woods, Parker S., Husain, Aliya N., Wolfgeher, Don, Dulin, Nickolai O., Chandel, Navdeep S., Mutlu, Gökhan M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2016
Aiheet:
Cell Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207151/
https://ncbi.nlm.nih.gov/pubmed/27836973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.756247
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