Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production

TGF-β promotes excessive collagen deposition in fibrotic diseases such as idiopathic pulmonary fibrosis (IPF). The amino acid composition of collagen is unique due to its high (33%) glycine content. Here, we report that TGF-β induces expression of glycolytic genes and increases glycolytic flux. TGF-...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Nigdelioglu, Recep, Hamanaka, Robert B., Meliton, Angelo Y., O'Leary, Erin, Witt, Leah J., Cho, Takugo, Sun, Kaitlyn, Bonham, Catherine, Wu, David, Woods, Parker S., Husain, Aliya N., Wolfgeher, Don, Dulin, Nickolai O., Chandel, Navdeep S., Mutlu, Gökhan M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207151/
https://ncbi.nlm.nih.gov/pubmed/27836973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.756247
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares