Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts

Idiopathic pulmonary fibrosis (IPF) is characterized by the transforming growth factor (TGF)-β–dependent differentiation of lung fibroblasts into myofibroblasts, leading to excessive deposition of extracellular matrix proteins, which distort lung architecture and function. Metabolic reprogramming in...

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Dades bibliogràfiques
Publicat a:Am J Respir Cell Mol Biol
Autors principals: Hamanaka, Robert B., O’Leary, Erin M., Witt, Leah J., Tian, Yufeng, Gökalp, Gizem A., Meliton, Angelo Y., Dulin, Nickolai O., Mutlu, Gökhan M.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2019
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827066/
https://ncbi.nlm.nih.gov/pubmed/30973753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0008OC
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