Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production

TGF-β promotes excessive collagen deposition in fibrotic diseases such as idiopathic pulmonary fibrosis (IPF). The amino acid composition of collagen is unique due to its high (33%) glycine content. Here, we report that TGF-β induces expression of glycolytic genes and increases glycolytic flux. TGF-...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Nigdelioglu, Recep, Hamanaka, Robert B., Meliton, Angelo Y., O'Leary, Erin, Witt, Leah J., Cho, Takugo, Sun, Kaitlyn, Bonham, Catherine, Wu, David, Woods, Parker S., Husain, Aliya N., Wolfgeher, Don, Dulin, Nickolai O., Chandel, Navdeep S., Mutlu, Gökhan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207151/
https://ncbi.nlm.nih.gov/pubmed/27836973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.756247
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