Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3–Rac1 Signaling

Rationale: Acute respiratory distress syndrome (ARDS) is caused by widespread endothelial barrier disruption and uncontrolled cytokine storm. Genome-wide association studies (GWAS) have linked multiple genes to ARDS. Although mechanosensitive transcription factor Krüppel-like factor 2 (KLF2) is a ma...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Huang, Ru-Ting, Wu, David, Meliton, Angelo, Oh, Myung-Jin, Krause, Matthew, Lloyd, Joyce A., Nigdelioglu, Recep, Hamanaka, Robert B., Jain, Mukesh K., Birukova, Anna, Kress, John P., Birukov, Konstantin G., Mutlu, Gökhan M., Fang, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363977/
https://ncbi.nlm.nih.gov/pubmed/27855271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201604-0668OC
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