HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium

Hemodynamic forces regulate vascular functions. Disturbed flow (DF) occurs in arterial bifurcations and curvatures, activates endothelial cells (ECs), and results in vascular inflammation and ultimately atherosclerosis. However, how DF alters EC metabolism, and whether resulting metabolic changes in...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Wu, David, Huang, Ru-Ting, Hamanaka, Robert B, Krause, Matt, Oh, Myung-Jin, Kuo, Cheng-Hsiang, Nigdelioglu, Recep, Meliton, Angelo Y, Witt, Leah, Dai, Guohao, Civelek, Mete, Prabhakar, Nanduri R, Fang, Yun, Mutlu, Gökhan M
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495571/
https://ncbi.nlm.nih.gov/pubmed/28556776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25217
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