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Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity
Therapeutic proteins of wide-ranging function hold great promise for treating disease, but immune surveillance of these macromolecules can drive an antidrug immune response that compromises efficacy and even undermines safety. To eliminate widespread T-cell epitopes in any biotherapeutic and thereby...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5495236/ https://ncbi.nlm.nih.gov/pubmed/28607051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621233114 |
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