Globally deimmunized lysostaphin evades human immune surveillance and enables highly efficacious repeat dosing

There is a critical need for novel therapies to treat methicillin-resistant Staphylococcus aureus (MRSA) and other drug-resistant pathogens, and lysins are among the vanguard of innovative antibiotics under development. Unfortunately, lysins’ own microbial origins can elicit detrimental antidrug ant...

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Pubblicato in:Sci Adv
Autori principali: Zhao, Hongliang, Brooks, Seth A., Eszterhas, Susan, Heim, Spencer, Li, Liang, Xiong, Yan Q., Fang, Yongliang, Kirsch, Jack R., Verma, Deeptak, Bailey-Kellogg, Chris, Griswold, Karl E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467700/
https://ncbi.nlm.nih.gov/pubmed/32917596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb9011
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