Structure and Dynamics of Type III Secretion Effector Protein ExoU As determined by SDSL-EPR Spectroscopy in Conjunction with De Novo Protein Folding

[Image: see text] ExoU is a 74 kDa cytotoxin that undergoes substantial conformational changes as part of its function, that is, it has multiple thermodynamically stable conformations that interchange depending on its environment. Such flexible proteins pose unique challenges to structural biology:...

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Publié dans:ACS Omega
Auteurs principaux: Fischer, Axel W., Anderson, David M., Tessmer, Maxx H., Frank, Dara W., Feix, Jimmy B., Meiler, Jens
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2017
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5494639/
https://ncbi.nlm.nih.gov/pubmed/28691114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00349
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