Characterization of the ExoU activation mechanism using EPR and integrative modeling

ExoU, a type III secreted phospholipase effector of Pseudomonas aeruginosa, serves as a prototype to model large, dynamic, membrane-associated proteins. ExoU is synergistically activated by interactions with membrane lipids and ubiquitin. To dissect the activation mechanism, structural homology was...

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Pubblicato in:Sci Rep
Autori principali: Tessmer, Maxx H., DeCero, Samuel A., del Alamo, Diego, Riegert, Molly O., Meiler, Jens, Frank, Dara W., Feix, Jimmy B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7665212/
https://ncbi.nlm.nih.gov/pubmed/33184362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76023-3
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