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Moderate Expression of SEC16 Increases Protein Secretion by Saccharomyces cerevisiae

The yeast Saccharomyces cerevisiae is widely used to produce biopharmaceutical proteins. However, the limited capacity of the secretory pathway may reduce its productivity. Here, we increased the secretion of a heterologous α-amylase, a model protein used for studying the protein secretory pathway i...

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Pubblicato in:Appl Environ Microbiol
Autori principali: Bao, Jichen, Huang, Mingtao, Petranovic, Dina, Nielsen, Jens
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5494634/
https://ncbi.nlm.nih.gov/pubmed/28476767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.03400-16
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