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Superoxide is the critical driver of DOPAL autoxidation, lysyl adduct formation, and crosslinking of α-synuclein
Parkinson’s disease has long been associated with redox imbalance and oxidative stress in dopaminergic neurons. The catecholaldehyde hypothesis proposes that 3,4-dihydroxyphenylacetaldehyde (DOPAL), an obligate product of dopamine catabolism, is a central nexus in a network of pathways leading to di...
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| Pubblicato in: | Biochem Biophys Res Commun |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5494600/ https://ncbi.nlm.nih.gov/pubmed/28412346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2017.04.050 |
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