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Isoindole linkages provide a pathway for DOPAL-mediated crosslinking of α-synuclein
3,4-dihydroxyphenylacetaldehyde (DOPAL) is a toxic and reactive product of dopamine catabolism. In the catecholaldehyde hypothesis for Parkinson’s disease, it is a critical driver of the selective loss of dopaminergic neurons that characterizes the disease. DOPAL also crosslinks α-synuclein, the mai...
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| 發表在: | Biochemistry |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6120588/ https://ncbi.nlm.nih.gov/pubmed/29394048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b01164 |
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