Phosphoinositide 3-Kinase Catalytic Subunit Deletion and Regulatory Subunit Deletion Have Opposite Effects on Insulin Sensitivity in Mice

Studies ex vivo have shown that phosphoinositide 3-kinase (PI3K) activity is necessary but not sufficient for insulin-stimulated glucose uptake. Unexpectedly, mice lacking either of the PI3K regulatory subunits p85α or p85β exhibit increased insulin sensitivity. The insulin hypersensitivity is parti...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Brachmann, Saskia M., Ueki, Kohjiro, Engelman, Jeffrey A., Kahn, Ronald C., Cantley, Lewis C.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2005
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC549361/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15713620/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.25.5.1596-1607.2005
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