Single-Dose Pharmacokinetics and Metabolism of [(14)C]Remofovir in Rats and Cynomolgus Monkeys

Single-dose pharmacokinetics and metabolism of [(14)C]remofovir was studied in rats and monkeys following intravenous (i.v.) and oral administration (30 mg/kg of body weight). Oral absorption and bioavailability were 29.7 and 5.42% in rats and 65.6 and 19.4% in monkeys, respectively. Following i.v....

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Lin, Chin-Chung, Xu, Christine, Zhu, Nanqun, Lourenco, David, Yeh, Li-Tain
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2005
Schlagworte:	Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC549278/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15728885/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.49.3.925-930.2005
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