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Efficacy and Toxicity of Zinc Salts as Candidate Topical Microbicides against Vaginal Herpes Simplex Virus Type 2 Infection

Zinc salt solutions administered as topical microbicides provided significant protection against herpes simplex virus type 2 infection in a mouse vaginal challenge model. However, at the therapeutic concentration, the salt solutions caused sloughing of sheets of vaginal epithelial cells. These obser...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Bourne, Nigel, Stegall, Rachael, Montano, Raquel, Meador, Michael, Stanberry, Lawrence R., Milligan, Gregg N.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2005
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC549274/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15728922/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.49.3.1181-1183.2005
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