Efficacy and Toxicity of Zinc Salts as Candidate Topical Microbicides against Vaginal Herpes Simplex Virus Type 2 Infection

Zinc salt solutions administered as topical microbicides provided significant protection against herpes simplex virus type 2 infection in a mouse vaginal challenge model. However, at the therapeutic concentration, the salt solutions caused sloughing of sheets of vaginal epithelial cells. These obser...

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Detalhes bibliográficos
Main Authors: Bourne, Nigel, Stegall, Rachael, Montano, Raquel, Meador, Michael, Stanberry, Lawrence R., Milligan, Gregg N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC549274/
https://ncbi.nlm.nih.gov/pubmed/15728922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.3.1181-1183.2005
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