Pulmonary Damage and Bacterial Load in Assessment of the Efficacy of Simulated Human Treatment-Like Amoxicillin (2,000 Milligrams) Therapy of Experimental Pneumococcal Pneumonia Caused by Strains for Which Amoxicillin MICs Differ

An experimental rat pneumonia model using two amoxicillin-susceptible (MICs, ≤0.015 and 2 μg/ml) and two non-amoxicillin-susceptible (MIC, 4 μg/ml) Streptococcus pneumoniae strains was developed for testing the efficacy of amoxicillin administered to simulate human serum kinetics after treatment wit...

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Bibliographic Details
Main Authors: Gracia, Matilde, Martínez-Marín, Carmina, Huelves, Lorena, Giménez, Maria J., Aguilar, Lorenzo, Carcas, Antonio, Ponte, Carmen, Soriano, Francisco
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC549246/
https://ncbi.nlm.nih.gov/pubmed/15728894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.3.996-1001.2005
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